The PDE12 antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to PDE12, and phosphodiesterase 12. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The PDE12 antibody has been validated for the following applications: EIA, Immunoassay, ELISA, Immunofluorescence, and Western Blot.
Description
Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons(IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system